James C Eisenach Selected Research

Gabapentin (Neurontin)

9/2019	Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement.
1/2018	Descending Noradrenergic Inhibition: An Important Mechanism of Gabapentin Analgesia in Neuropathic Pain.
1/2016	Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
10/2014	Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
6/2014	Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.
6/2012	Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
1/2011	A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
9/2010	Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.
12/2008	Gabapentin acts within the locus coeruleus to alleviate neuropathic pain.
11/2008	Multiplicative interactions to enhance gabapentin to treat neuropathic pain.

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James C Eisenach Research Topics

Disease

69	Hypersensitivity (Allergy) 01/2021 - 01/2000
66	Pain (Aches) 11/2021 - 01/2000
46	Neuralgia (Stump Neuralgia) 01/2019 - 01/2002
30	Peripheral Nerve Injuries 01/2018 - 01/2002
24	Hyperalgesia 01/2015 - 01/2000
22	Postoperative Pain 01/2021 - 01/2000
18	Chronic Pain 11/2021 - 01/2002
12	Inflammation (Inflammations) 01/2021 - 10/2002
10	Acute Pain 08/2021 - 01/2000
6	Visceral Pain 11/2006 - 02/2002
5	Surgical Wound 01/2021 - 03/2006
3	Headache (Headaches) 03/2012 - 01/2002
3	Nausea 08/2009 - 01/2003
3	Neuritis (Polyneuritis) 07/2007 - 09/2005
2	Respiratory Insufficiency (Respiratory Failure) 11/2021 - 02/2005
2	Phantom Limb (Phantom Limbs) 10/2021 - 01/2021
2	Alzheimer Disease (Alzheimer's Disease) 06/2007 - 05/2007
2	Wallerian Degeneration 02/2006 - 11/2005
2	Wounds and Injuries (Trauma) 09/2005 - 01/2003
2	Labor Pain 02/2004 - 10/2002
2	Back Pain (Backache) 09/2003 - 01/2002
1	Opioid-Related Disorders (Opiate Addiction) 11/2021
1	Neoplasm Metastasis (Metastasis) 01/2021

Drug/Important Bio-Agent (IBA)

24	Clonidine (ST 155)FDA LinkGeneric 01/2015 - 01/2000
18	Opioid Analgesics (Opioids)IBA 11/2021 - 02/2002
18	Analgesics (Analgesic Drugs)IBA 05/2019 - 07/2003
16	Adenosine (Adenocard)FDA LinkGeneric 01/2015 - 01/2002
12	Pharmaceutical PreparationsIBA 01/2021 - 01/2000
12	Morphine (MS Contin)FDA LinkGeneric 01/2021 - 06/2003
12	Gabapentin (Neurontin)FDA LinkGeneric 09/2019 - 03/2007
11	KetorolacIBA 01/2015 - 03/2002
10	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2021 - 09/2002
10	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2015 - 05/2002
9	ProstaglandinsIBA 01/2015 - 03/2002
8	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2018 - 08/2002
8	Capsaicin (Zostrix)FDA Link 01/2015 - 01/2000
7	Glutamic Acid (Glutamate)FDA Link 01/2018 - 12/2008
7	Cholinergic Agents (Cholinergics)IBA 01/2013 - 06/2007
6	Local AnestheticsIBA 10/2021 - 01/2003
6	Purinergic P1 Receptors (Adenosine Receptor)IBA 11/2005 - 06/2002
5	Cyclooxygenase InhibitorsIBA 01/2015 - 09/2003
5	Adenosine A1 ReceptorIBA 10/2006 - 05/2002
5	Cyclooxygenase 1IBA 03/2006 - 07/2003
4	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 01/2021 - 07/2004
4	Oxytocin (Pitocin)FDA LinkGeneric 01/2018 - 01/2013
4	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2013 - 05/2003
4	Donepezil (Aricept)FDA LinkGeneric 01/2013 - 05/2007
4	Estrogens (Estrogen)FDA Link 05/2007 - 02/2002
4	CytokinesIBA 08/2006 - 09/2005
3	Mixed Function Oxygenases (Monooxygenases)IBA 02/2016 - 01/2011
3	Dopamine (Intropin)FDA LinkGeneric 02/2016 - 01/2011
3	SaporinsIBA 02/2016 - 01/2012
3	Valproic Acid (Depakote)FDA LinkGeneric 01/2016 - 09/2011
3	gamma-Aminobutyric Acid (GABA)IBA 01/2013 - 06/2012
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2013 - 05/2007
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2011 - 06/2008
3	Neostigmine (Neostigmine Bromide)IBA 08/2009 - 02/2004
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 05/2009 - 02/2004
3	Atropine FDA LinkGeneric 06/2007 - 07/2003
3	GTP-Binding Proteins (G-Protein)IBA 05/2007 - 06/2002
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 11/2003 - 07/2003
2	Ropivacaine (Naropin)FDA LinkGeneric 10/2021 - 10/2002
2	salicylhydroxamic acid (SHAM)IBA 08/2021 - 01/2021
2	Substance PIBA 01/2021 - 01/2019
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018 - 08/2002
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 02/2004
2	Naloxone (Narcan)FDA LinkGeneric 03/2016 - 01/2013
2	Remifentanil (Ultiva)FDA Link 01/2015 - 09/2003
2	Dinoprostone (PGE2)FDA Link 01/2015 - 05/2010
2	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 11/2013 - 09/2011
2	Aminobutyrates (Aminobutyric Acid)IBA 01/2013 - 08/2012
2	Ondansetron (Zofran)FDA LinkGeneric 08/2012 - 09/2010
2	5-HT3 Serotonin Receptors (5 HT3 Receptor)IBA 08/2012 - 09/2010
2	Riluzole FDA LinkGeneric 09/2011 - 03/2010
2	Nerve Growth Factor (NGF)IBA 01/2011 - 08/2010
2	IdazoxanIBA 03/2010 - 02/2005
2	CarrageenanIBA 05/2009 - 06/2003
2	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 05/2007 - 05/2003
2	Muscarinic M4 ReceptorIBA 01/2007 - 05/2003
2	EnzymesIBA 02/2005 - 10/2004
2	Antisense OligonucleotidesIBA 01/2005 - 10/2003
2	Milnacipran (Ixel)FDA Link 05/2004 - 03/2004
2	Antidepressive Agents (Antidepressants)IBA 05/2004 - 03/2004
2	Proteins (Proteins, Gene)FDA Link 02/2004 - 07/2003
2	IsoenzymesIBA 11/2003 - 10/2002
1	A-factor (Streptomyces)IBA 08/2021

Therapy/Procedure

39	Analgesia 12/2020 - 01/2000
30	Ligation 09/2019 - 05/2002
16	Spinal Injections 01/2013 - 01/2002
7	Therapeutics 05/2013 - 01/2003
6	Laparotomy 10/2011 - 07/2004
4	Oral Administration 11/2013 - 05/2002
3	Aftercare (After-Treatment) 10/2021 - 07/2007
3	Anesthesia 01/2021 - 05/2010
2	Catheters 10/2021 - 02/2005
2	Surgical Amputation (Amputations) 10/2021 - 01/2021
2	Orthopedic Procedures 08/2021 - 01/2021
2	Self Administration (Administration, Self) 02/2007 - 12/2006
2	Cesarean Section (Caesarean Section) 03/2006 - 02/2004
1	Ambulatory Surgical Procedures (Outpatient Surgery) 08/2021